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Thursday, April 23, 2020 | History

5 edition of Iminosugars as glycosidase inhibitors found in the catalog.

Iminosugars as glycosidase inhibitors

Nojirimycin and beyond

by

  • 190 Want to read
  • 20 Currently reading

Published by Wiley-VCH in Weinheim, New York .
Written in English

    Subjects:
  • Glycosidases -- Inhibitors.,
  • Imino compounds -- Physiological effect.

  • Edition Notes

    StatementArnold E. Stütz ; with a foreword by H. Paulsen.
    ContributionsStütz, Arnold E.
    Classifications
    LC ClassificationsQP609.G45 .I45 1999
    The Physical Object
    Paginationxiv, 397 p. :
    Number of Pages397
    ID Numbers
    Open LibraryOL81526M
    ISBN 103527295445
    LC Control Number99186689

    @article{osti_, title = {Binding of 3,4,5,6-Tetrahydroxyazepanes to the Acid-[beta]-glucosidase Active Site: Implications for Pharmacological Chaperone Design for Gaucher Disease}, author = {Orwig, Susan D and Tan, Yun Lei and Grimster, Neil P and Yu, Zhanqian and Powers, Evan T and Kelly, Jeffery W and Lieberman, Raquel L and GIT)}, abstractNote = {Pharmacologic chaperoning is a.


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Iminosugars as glycosidase inhibitors Download PDF EPUB FB2

A table which lists over glycosidase inhibitors, more than enzymes with citations and over invaluable sets of data completes the book. Author Bios Arnold E. Stütz and H. Paulsen are the authors of Iminosugars as Glycosidase Inhibitors: Nojirimycin and Beyond, published by Wiley.

Iminosugars as Glycosidase Inhibitors Nojirimycin and Beyond Edited by Arnold E. Stütz "Nowadays as a result of these manifold Iminosugars as glycosidase inhibitors book efforts Iminosugars as glycosidase inhibitors book large number of inhibitors are available, that can be applied selectively for many different : Iminosugars as glycosidase inhibitors book.

Iminosugars as powerful glycosidase inhibitors- synthetic approaches from aldonolactones-- Sec. Isoiminosugars: glycosidase inhibitors with nitrogen at the anomeric position-- Sec. Synthesis and biological activity of castanospermine and close Iminosugars as glycosidase inhibitors book.

\/span>\"@ en \/a> ; \u00A0\u00A0\u00A0\n schema:description \/a> \" Sec. An iminosugar, also known as an iminosaccharide, is any analog of a sugar where a nitrogen atom has replaced the oxygen atom in the ring of the structure.

Iminosugars are common components of plants and may be responsible for some of their medicinal properties. The first iminosugar to be isolated from a natural source, 1-deoxynojirimycin (DNJ), found in Mulberry, was reported inbut few.

A table of more than glycosidase inhibitors completes the book. From the Back Cover Iminosugars as Glycosidase Inhibitors Nojirimycin and Beyond Edited by Arnold E.

Stütz "Nowadays as a result of these manifold synthetic efforts a Iminosugars as glycosidase inhibitors book number of inhibitors are available, that can be applied selectively for many different Iminosugars as glycosidase inhibitors book Hardcover.

Since the discovery of their biological activity as glycosidase inhibitors in the ’s, these polyvalent molecules have progressively made their way from the laboratory to the clinic.

The impressive series of discoveries in the field over the past ten years indicates clearly that it is “a boom time” for iminosugar chemistry and biology. The book will be a generally interesting source of information for chemists and biochemists.' (from the foreword by H.

Paulsen). A table which lists over glycosidase inhibitors, more than enzymes with citations and over invaluable sets of data completes the book.

Although initially recognised as one of the largest families of glycosidase inhibitors, they are increasingly being found to interact with many other biological processes involving sugars, including interacting with carbohydrate receptors without inhibiting glycosidases.

Iminosugars have proven value and great potential as chemotherapeutic agents. Some recent examples of advances in the area of iminosugars include the synthesis of some bicyclic analogues of nojirimycin (Cipolla et al., ).Bicyclic iminosugars are believed to have potent glycosidase inhibitory activity because of the extra rigidity in the structures and the fact Iminosugars as glycosidase inhibitors book the iminosugar ring often adopts a flattened-chair type conformation.

Since the discovery of their biological activity as glycosidase inhibitors in the ’s, these polyvalent molecules have progressively made their way from the laboratory to the clinic. The impressive series of discoveries in the field over the past ten years indicates clearly that it is “a boom time” for iminosugar chemistry and : Hardcover.

Iminosugars as Glycosidase Inhibitors: Nojirimycin & Beyond by n/a and a great selection of related books, art and collectibles available now at Iminosugars form undoubtedly the most attractive of Iminosugars as glycosidase inhibitors book mimics reported so far. In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis.

Since the discovery of their biological activity as glycosidase inhibitors in the ’s, these polyvalent molecules. Glycosidase inhibitors are proving to be useful tools for research dealing with GSL lysosomal storage diseases, and such inhibitors may prove to be valuable in the therapy of these diseases as well.

GSL are ubiquitous components of all the cellular membranes of eukaryotic cells, and some different glycolipid structures have now been identified. Although these GSLs make only a small.

Glycosidase inhibitory activities of imino-C-disaccharides. Efficient combinatorial method for the discovery of glycosidase inhibitors. Antitumour activity of new a-mannosidase inhibitors. Conclusion. References. Isofagomine, noeuromycin and other 1-azasugars, iminosugar related glycosidase inhibitors (Oscar Lopez and Mikael.

Abstract: Glycosidases have important anti-cancer, anti-viral and anti-diabetic properties. This review covers the literature in the past 15 years since our initial review in this journal on “neutral” glycosidase inhibitors lacking a basic nitrogen found in iminosugars and azasugars or inhibitors that are neutral by virtue of being “charge-balanced” (zwitterionic).Cited by: 3.

Iminosugars have been recognized as a class of potent inhibitors of glycosidase enzymes (Houston & Blanchfield ; Zechel et al., ; de Melo et al., ; Compain and Martin, ).These. Iminosugars form undoubtedly the most attractive of carbohydrate mimics reported so far.

In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis. Since the discovery of their biological activity as glycosidase inhibitors in the 's, these polyvalent molecules.

Title: Combinatorial Approaches to Iminosugars as Glycosidase and Glycosyltransferase Inhibitors VOLUME: 9 ISSUE: 8 Author(s):Maria Gregori, Barbara La Ferla and Laura Cipolla Affiliation:Department of Biotechnology and Biosciences, University of Milano-Bicocca, della Scienza 2, Milano, Italy.

Keywords:iminosugar libraries, enzyme inhibitors, glycosyltransferases, glycosidases. In book: Iminosugars as Glycosidase Inhibitors: Nojirimycin and Beyond, pp - Cite this publication. Inge Lundt. ; acting as potent glycosidase inhibitors, have made considerable.

Azetidine- and N-carboxylic azetidine-iminosugars as amyloglucosidase inhibitors: synthesis, glycosidase inhibitory activity and molecular docking studies† Kishor S.

Gavale, a Shrawan R. Chavan, a Ayesha Khan, a Rakesh Joshi b and Dilip D. Dhavale * a. We report the synthesis of two novel families of iminosugars as glycosidase inhibitors involving an intramolecular cyclization between an N-alkoxyamino group and a latent aldehyde of a reducing sugar as the key step.

Using this methodology we have prepared the hitherto unknown bicyclic polyhydroxylated N-(methoxy, benzyloxy)anhydroazepanes and N-benzyloxy-D-xylonojirimycin; all these novel.

Cipolla L, La Ferla B, Gregori M () Combinatorial approaches to iminosugars as glycosidase and glycosyltransferase inhibitors. Comb Chem High Throughput Screen 9(8)– Google Scholar Cited by: 6.

Table of contents for Iminosugars: from synthesis to therapeutic applications / edited by Philippe Compain and Olivier R. Martin. Contents may have variations from the printed book or be incomplete or contain other coding. iminosugar related glycosidase inhibitors Oscar Lopez and Mikael Bols Introduction 1-Azasugars that are.

Carbohydrate-derived nitrones as synthetic tools for the discovery of novel classes of iminosugars Due to their stability in vivo and their activity as glycosidase inhibitors or activators, iminosugars are among the most promising drug candidates for the treatment of diseases such as diabetes, viral infections and lysosomal storage.

Discover Book Depository's huge selection of Arnold Stutz books online. Free delivery worldwide on over 20 million titles. We use cookies to give you the best possible experience.

Iminosugars as Glycosidase Inhibitors. Arnold Stutz. 24 Mar unavailable. Try AbeBooks. Iminosugars as Glycosidase Inhibitors. Since the discovery of their biological activity as glycosidase inhibitors in the ’s, these polyvalent molecules have progressively made their way from the laboratory to the clinic.

The impressive series of discoveries in the field over the past ten years indicates clearly that it is “a boom time” for iminosugar chemistry and biology.

Abstract. From their discovery in the late s, iminosugars have undergone an expansion from an area of science limited to a few researchers to a field that now attracts the interest of members of the whole synthetic organic chemistry : Damien Hazelard, Raphaël Hensienne, Jean-Bernard Behr, Philippe Compain.

Book Reviews FWENDY KNIGHT. Managed Care: What It Is and How It Works. Gaithersburg MD: An Aspen Publication, xi + pp., 16 figs., 12 tbls., $ In this appropriately titled book Wendy Knight takes a complex topic and presents it in a logical, coherent manner.

While Knight has extensive. Efficient ring closure of stable crystalline 3,5-di-O-triflates of pentofuranosides with amines to form azetidines allowed preliminary evaluation of four-ring iminosugars as glycosidase inhibitors; significant and specific inhibition of nonmammalian α-glucosidases is shown by l-xylo.

Glycosidase inhibition by basic sugar analogs and the transition state of enzymatic glycoside hydrolysis-- Sec. Synthetic methods for the preparation of iminosugars-- Sec. Iminosugars as powerful glycosidase inhibitors- synthetic approaches from aldonolactones-- Sec.

The aim of this book is to present the multifaceted aspects of iminosugars from structure to biological activities and from synthesis to therapeutic applications. Chapter 2 focus on naturally occurring iminosugars.

Chapter 3 is devoted to recent synthetic strategies and combinatorial approaches towards iminosugar libraries. John Wiley & Sons, Hoboken pp., hardcover € —ISBN ‐0‐‐‐3 Iminosugars have been the subject of intensive studies at the interface between organic synthesis, glycobiology, and medical science since the discovery of their remarkable biological activities as glycosidase inhibitors in the s.

In the last ten years the rate of discoveries has Author: Krämer, Katja. Biosynthetic Pathways to Glycosidase Inhibitors Fernando Gomollón-Bel, Ignacio Delso, Tomás Tejero and Pedro Merino* [23] and a chapter book,[24] covering literature from to middle and up torespectively. Since then there has not been in the biosynthesis of both iminosugars is the isomerization of glucose to fructose.

Synthesis of iminosugars 1, 2, 3a, and 4a and N-alkyl (ethyl, butyl, hexyl, octyl, decyl, and dodecyl) derivatives 3b–g and 4b–g spiro-linked with morpholine-fused 1,2,3-triazole is described. Conformation of the piperidine ring in each spiro-iminosugar was evaluated by 1H NMR spectroscopy, and conformational change in N-alkylated compounds 4b–g with respect to parent spiro-iminosugar 4a Cited by: 5.

Since the discovery of their biological activity as glycosidase inhibitors in the 's, these polyvalent molecules have progressively made their way from the laboratory to the clinic.

The impressive series of discoveries in the field over the past ten years indicates clearly that it is "a boom time" for iminosugar chemistry and biology. A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern (d-gluco or l-ido), the architecture of the glycone skeleton, and the nature of the nonglycone substituent has been synthesized and assayed for their inhibition properties towards commercial glycosidases.

On the basis of their affinity and selectivity towards GH1 &beta Cited by: Nojirimycin is the parent compound of a class of antibiotics and glycosidase mycin and its derivatives are mainly obtained from a class of Streptomyces species. Chemically, it is an iminosugar. Derivatives.

1-deoxynojirimycin or duvoglustat; 1-deoxygalactonojirimycin or migalastat, a drug for the treatment of Fabry disease; ReferencesCAS Number: Hermen Overkleeft.

Scientific director / professor of Bio-organic synthesis. (University of Amsterdam) on the subject of iminosugars as glycosidase inhibitors.

He then did post-doctoral research with Professor Jacques van Boom (Leiden University, the Netherlands, ) on ring-closing metathesis in the synthesis of polyhydroxylated. Hence, modifying or blocking these processes in vivo by inhibitors is of great interest from a therapeutic point of view.

Azasugars are an important class of glycosidase inhibitors and are arousing great interest for instance as antidiabetics, antiobesity drugs, antivirals, and. @article{osti_, title = {Effects of pH and Iminosugar Pharmacological Chaperones on Lysosomal Glycosidase Structure and Stability}, author = {Lieberman, Raquel L and D aquino, J Alejandro and Ringe, Dagmar and Petsko, Gregory A and Harvard-Med) and Brandeis)}, abstractNote = {Human lysosomal enzymes acid-{beta}-glucosidase (GCase) and acid-{alpha}-galactosidase ({alpha}-Gal A).

You can write a book review and pdf your experiences. Other readers will always pdf interested in your opinion of the books you've read. Whether you've loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them., Free ebooks since   Such compounds have been shown to demonstrate exquisite selectivity and potent activity as glycosidase inhibitors for example towards GCase, the enzyme involved in Gaucher disease.

In recent work, we have demonstrated that N-sulfinylglycosylamines constituted favorable precursors for the stereocontrolled synthesis of iminosugar-C-glycosides of.Abstract.

A novel gram-scale synthesis of ebook from tetra-O-benzyl-d-glucopyranose in 9 steps and 28% overall yield with a limited number of purification steps is synthetic strategy is based on the regioselective deprotection and subsequent inversion of configuration of the OH group at C-2 in tetra-O-benzyl-d-glucono-δ-lactam, also an advanced intermediate toward.